Wyoming vs. Colorado prediction: Why Colorado is favored to win in college football Week 4, 2025

Colorado and Wyoming will meet in Week 4 college football action at Folsom Field on Saturday, starting at 10:15PM ET.

Based on updated simulation results, Dimers' proven college football model predicts Colorado as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Wyoming vs. Colorado predictions page.

Wyoming vs. Colorado prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the result of Wyoming vs. Colorado 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives Colorado a 76% chance of beating Wyoming. Our predicted final score has Colorado winning 27-18.

According to our model, Wyoming (+12.5) has a 57% chance of covering the spread, while the over/under total of 45.5 points has a 52% chance of staying under.

Wyoming vs. Colorado odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Wyoming	Colorado
Spread	+12.5 (-112)	-12.5 (-105)
Moneyline	+375	-450
Total	o45.5 (-110)	u45.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Wyoming vs. Colorado picks and best bets

Our model's biggest edge in today's Wyoming vs. Colorado matchup is on the over/under.

Our expert predictions, matched against the latest odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Wyoming vs. Colorado game-day updates and essential details

Saturday's college football matchup between Colorado and Wyoming at Folsom Field is scheduled to start at 10:15PM ET.

• Who: Wyoming vs. Colorado
• Date: Saturday, September 20, 2025
• Time: 10:15PM ET/7:15PM PT
• Venue: Folsom Field

Dimers' comprehensive preview of Saturday's Wyoming vs. Colorado matchup includes our prediction, picks and the latest betting odds.

Before making any Wyoming vs. Colorado picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Colorado, with a 76% win probability, will likely beat Wyoming on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Wyoming vs. Colorado insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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