William & Mary vs. Villanova prediction: Villanova favored to win in college football Week 5, 2025

Villanova will face William & Mary in Week 5 college football action at Villanova Stadium on Saturday, beginning at 3:30PM ET.

Based on the latest simulations, Dimers' proven college football model projects Villanova as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive William & Mary vs. Villanova predictions page.

William & Mary vs. Villanova prediction: Who will win, cover the spread?

Using powerful machine learning and data, we have simulated the outcome of William & Mary vs. Villanova 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives Villanova a 66% chance of defeating William & Mary. Our predicted final score has Villanova winning 27-21.

According to our model, William & Mary (+6.5) has a 52% chance of covering the spread, while the 48.5-point over/under has an equal 50-50 chance of hitting.

William & Mary vs. Villanova odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	William & Mary	Villanova
Spread	+6.5 (-110)	-6.5 (-110)
Moneyline	+200	-225
Total	o48.5 (-110)	u48.5 (-110)

All odds are correct at the time of publication and are subject to change.

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William & Mary vs. Villanova picks and best bets

Our model's strongest edge in today's William & Mary vs. Villanova matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

William & Mary vs. Villanova game-day updates and essential details

Saturday's college football action between Villanova and William & Mary at Villanova Stadium is scheduled to start at 3:30PM ET.

• Who: William & Mary vs. Villanova
• Date: Saturday, September 27, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: Villanova Stadium

Dimers' in-depth preview of Saturday's William & Mary vs. Villanova matchup includes our prediction, picks and the latest betting odds.

Before making any William & Mary vs. Villanova picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict Villanova, with a 66% win probability, will likely beat William & Mary on Saturday.

AI and automation have enhanced this article to quickly deliver accurate William & Mary vs. Villanova insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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