Western Illinois vs. Northwestern prediction: Northwestern favored to win in college football Week 2, 2025

Northwestern and Western Illinois will lock horns in Week 2 college football action at Northwestern Medicine Field at Martin Stadium on Friday, commencing at 7:30PM ET.

Based on updated simulations, Dimers' advanced college football model predicts Northwestern as the most likely winner of today's game.

For further insights into Friday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Western Illinois vs. Northwestern predictions page.

Western Illinois vs. Northwestern prediction: Who will win, cover the spread?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Western Illinois vs. Northwestern 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives Northwestern a 98% chance of beating Western Illinois. Our predicted final score has Northwestern winning 40-9.

According to our model, Western Illinois (+31.5) has a 54% chance of covering the spread, while the 49.5-point over/under has a 55% chance of staying under.

Western Illinois vs. Northwestern odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Western Illinois	Northwestern
Spread	+31.5 (-105)	-31.5 (-108)
Moneyline	+5000	-10000
Total	o49.5 (-105)	u49.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Western Illinois vs. Northwestern picks and best bets

Our model's biggest edge in today's Western Illinois vs. Northwestern matchup is on the over/under.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Western Illinois vs. Northwestern game-day updates and essential details

Friday's college football game between Northwestern and Western Illinois at Northwestern Medicine Field at Martin Stadium is scheduled to begin at 7:30PM ET.

• Who: Western Illinois vs. Northwestern
• Date: Friday, September 5, 2025
• Time: 7:30PM ET/4:30PM PT
• Venue: Northwestern Medicine Field at Martin Stadium

Dimers.com's comprehensive preview of Friday's Western Illinois vs. Northwestern matchup includes our prediction, picks and the latest betting odds.

Before making any Western Illinois vs. Northwestern picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Northwestern, with a 98% win probability, will likely beat Western Illinois on Friday.

AI and automation have enhanced this article to quickly deliver accurate Western Illinois vs. Northwestern insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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