West Virginia vs. Ohio prediction: West Virginia favored to win in college football Week 2, 2025

Ohio will take on West Virginia in Week 2 college football action at Frank Solich Field at Peden Stadium on Saturday, starting at 4:00PM ET.

Based on the latest simulation results, Dimers' advanced college football model projects West Virginia as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive West Virginia vs. Ohio predictions page.

West Virginia vs. Ohio prediction: Who will win, cover the spread?

Using innovative machine learning and data, we have simulated the outcome of West Virginia vs. Ohio 10,000 times as part of our college football predictions coverage.

Our leading predictive model gives West Virginia a 51% chance of defeating Ohio. Our predicted score is West Virginia 28-28 Ohio.

According to our model, Ohio (+3.5) has a 61% chance of covering the spread, while the over/under total of 51.5 points has a 61% chance of going over.

While there is no way for a College Football game to end in a tie, our prediction of 28-28 is based on each team's average score in the above-mentioned simulations of West Virginia vs. Ohio.

West Virginia vs. Ohio odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	West Virginia	Ohio
Spread	-3.5 (-105)	+3.5 (-110)
Moneyline	-170	+140
Total	o51.5 (-106)	u51.5 (-125)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

West Virginia vs. Ohio picks and best bets

Our model's biggest edge in today's West Virginia vs. Ohio matchup is on the spread.

Our expert predictions, matched against the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

West Virginia vs. Ohio game-day updates and essential details

Saturday's college football matchup between Ohio and West Virginia at Frank Solich Field at Peden Stadium is scheduled to start at 4:00PM ET.

• Who: West Virginia vs. Ohio
• Date: Saturday, September 6, 2025
• Time: 4:00PM ET/1:00PM PT
• Venue: Frank Solich Field at Peden Stadium

Dimers.com's in-depth preview of Saturday's West Virginia vs. Ohio matchup includes our prediction, picks and the latest betting odds.

Before making any West Virginia vs. Ohio picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Sports betting deal available for NCAAF Saturday

To make the most of Saturday's big day of sports, headlined by clashes like this one for college football Saturday, check out details on the latest Bet365 bonus code "DIMERS" that scores you $300 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

We predict West Virginia, with a 51% win probability, will likely beat Ohio on Saturday.

AI and automation have enhanced this article to quickly deliver accurate West Virginia vs. Ohio insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on College Football

Keep up with the latest college football news and CFB parlay picks throughout the season. Plus, our College Football National Championship odds offer the most accurate predictions for the national title game and major conferences.