Nationals vs. Cardinals Prediction: St. Louis Predicted to Win Thursday's MLB Matchup [7/10/2025]

The St. Louis Cardinals and Washington Nationals will lock horns in MLB action at Busch Stadium on Thursday, starting at 7:45PM ET.

The Cardinals will have Miles Mikolas (4-6, 5.26 ERA) as their starting pitcher, up against Michael Soroka (3-6, 5.40 ERA) for the Nationals.

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Cardinals as the most likely winner of today's game.

For further insights into Thursday's matchup, including best bets and picks, visit our interactive Nationals vs. Cardinals predictions page.

Cardinals vs. Nationals Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data analysis, we have simulated the outcome of Thursday's MLB matchup between the Nationals and Cardinals 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Cardinals a 55% chance of defeating the Nationals.

According to our model, the Nationals (+1.5) have a 62% chance of covering the run line, while the over/under total of 9 runs has a 53% chance of staying under.

Nationals vs. Cardinals Odds [7/10/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Nationals	Cardinals
Run Line	+1.5 (-172)	-1.5 (+146)
Moneyline	+124	-140
Total	o9 (+100)	u9 (-115)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Nationals vs. Cardinals Picks and Best Bets

Our model's biggest edge in today's Nationals vs. Cardinals matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Nationals vs. Cardinals Game-Day Updates and Essential Details

Thursday's MLB game between the Cardinals and Nationals at Busch Stadium is scheduled to start at 7:45PM ET.

• Who: Washington Nationals vs. St. Louis Cardinals
• Date: Thursday, July 10, 2025
• Time: 7:45PM ET/4:45PM PT
• Venue: Busch Stadium

Dimers.com's full preview of Thursday's Nationals vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Nationals vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Plus, with sports betting in Missouri set to launch on December 1, 2025, Dimers has everything you need—from the latest updates and the best MO sports betting promos.

Conclusion

We predict the Cardinals, with a 55% win probability, will likely beat the Nationals on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Nationals vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay informed with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most up-to-date probabilities for the World Series, American League, National League and each division.