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Nationals vs. Mariners Prediction: Seattle Predicted to Win Wednesday's MLB Matchup [5/28/2025]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Our expert prediction for Wednesday's Washington Nationals vs Seattle Mariners matchup.
The Seattle Mariners will face the Washington Nationals in MLB action at T-Mobile Park on Wednesday, commencing at 9:40PM ET.
George Kirby (0-1, 12.27 ERA) will be the starting pitcher for the Mariners, while the Nationals are going with Trevor Williams (2-5, 6.38 ERA).
Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) projects the Mariners as the most likely winner of today's game.
"Our team has simulated the outcome of Wednesday's Washington-Seattle game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.
"With the latest updates and numerous other variables, we estimate the Mariners' chance of winning at 63%, with the Nationals at 37%."
For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Nationals vs. Mariners predictions page.
Mariners vs. Nationals Prediction: Who Will Win, Cover the Run Line?
Using powerful machine learning and data, we have simulated the outcome of Wednesday's MLB matchup between the Nationals and Mariners 10,000 times as part of our MLB predictions coverage.
Our leading predictive model currently gives the Mariners a 63% chance of defeating the Nationals.
According to our model, the Nationals (+1.5) have a 57% chance of covering the run line, while the over/under total of 7.5 runs has a 54% chance of going over.
Nationals vs. Mariners Odds [5/28/2025]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Nationals | Mariners |
|---|---|---|
| Run Line | +1.5 (-110) | -1.5 (+100) |
| Moneyline | +190 | -220 |
| Total | o7.5 (-122) | u7.5 (+100) |
All odds are correct at the time of publication and are subject to change.
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Nationals vs. Mariners Picks and Best Bets
Our model's strongest edge in today's Nationals vs. Mariners matchup is on the over/under.
Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.
Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.
Calling Our Shot's Best Bets Video
Calling Our Shot produces daily MLB betting content, including the free picks featured below.
Nationals vs. Mariners Game-Day Updates and Essential Details
Wednesday's MLB matchup between the Mariners and Nationals at T-Mobile Park is scheduled to begin at 9:40PM ET.
- Who: Washington Nationals vs. Seattle Mariners
- Date: Wednesday, May 28, 2025
- Time: 9:40PM ET/6:40PM PT
- Venue: T-Mobile Park
Dimers.com's in-depth preview of Wednesday's Nationals vs. Mariners matchup includes our prediction, picks and the latest betting odds.
Before making any Washington vs. Seattle picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.
Key MLB Betting Guides and Insights
- Explore how MLB odds work and dive into MLB live betting strategies
- Understand where sports odds come from and how they're applied to baseball matchups
- Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
- Stay informed with where online sports betting is currently legal and which betting sites are safest to use
- Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on
Conclusion
We predict the Mariners, with a 63% win probability, will likely beat the Nationals on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate Nationals vs. Mariners insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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More on MLB
Keep up with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds provide the latest probabilities for the World Series, American League, National League and each division.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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