Nationals vs. Padres Prediction: San Diego Predicted to Win Monday's MLB Matchup [6/23/2025]

The San Diego Padres and Washington Nationals are scheduled to meet in MLB action at PETCO Park on Monday, starting at 9:40PM ET.

The Padres will have Stephen Kolek (3-2, 3.59 ERA) as their starting pitcher, up against Mitchell Parker (4-8, 4.59 ERA) for the Nationals.

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Padres as the most likely winner of today's game.

"Our team has utilized the latest data to simulate Monday's Nationals-Padres game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Incorporating recent updates and thousands of additional inputs, our prediction shows the Padres are likely to win, with a probability of 61%, compared to the Nationals' 39%."

For a closer look at Monday's matchup, including best bets and picks, visit our interactive Nationals vs. Padres predictions page.

Padres vs. Nationals Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the result of Monday's MLB matchup between the Nationals and Padres 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Padres a 61% chance of beating the Nationals.

According to our model, the Nationals (+1.5) have a 58% chance of covering the run line, while the over/under total of 8.5 runs has an equal 50-50 chance of hitting.

Nationals vs. Padres Odds [6/23/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Nationals	Padres
Run Line	+1.5 (-133)	-1.5 (+116)
Moneyline	+156	-172
Total	o8.5 (-115)	u8.5 (+101)

All odds are correct at the time of publication and are subject to change.

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Nationals vs. Padres Picks and Best Bets

Our model's strongest edge in today's Nationals vs. Padres matchup is on the over/under.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Nationals vs. Padres Game-Day Updates and Essential Details

Monday's MLB action between the Padres and Nationals at PETCO Park is scheduled to commence at 9:40PM ET.

• Who: Washington Nationals vs. San Diego Padres
• Date: Monday, June 23, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers.com's full preview of Monday's Nationals vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Nationals vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Padres, with a 61% win probability, will likely beat the Nationals on Monday.

AI and automation have enhanced this article to quickly deliver accurate Nationals vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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