Nationals vs. Phillies prediction: Why Philadelphia is favored to win Friday's MLB matchup [8/22/2025]

The Philadelphia Phillies will face the Washington Nationals in MLB action at Citizens Bank Park on Friday, beginning at 6:45PM ET.

Taijuan Walker (4-6, 3.34 ERA) will be the starting pitcher for the Phillies, pitting him against Cade Cavalli (1-0, 2.20 ERA) for the Nationals.

Based on updated simulations, Dimers' advanced MLB model projects the Phillies as the most likely winner of today's game.

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Nationals vs. Phillies predictions page.

Phillies vs. Nationals prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the outcome of Friday's MLB matchup between the Nationals and Phillies 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Phillies a 62% chance of beating the Nationals.

According to our model, the Nationals (+1.5) have a 56% chance of covering the run line, while the 9-run over/under has a 55% chance of going over.

Nationals vs. Phillies odds [8/22/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Nationals	Phillies
Run Line	+1.5 (-120)	-1.5 (+102)
Moneyline	+165	-196
Total	o9 (-119)	u9 (+100)

All odds are correct at the time of publication and are subject to change.

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Nationals vs. Phillies picks and best bets

Our model's biggest edge in today's Nationals vs. Phillies matchup is on the over/under.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Nationals vs. Phillies game-day updates and essential details

Friday's MLB matchup between the Phillies and Nationals at Citizens Bank Park is scheduled to commence at 6:45PM ET.

• Who: Washington Nationals vs. Philadelphia Phillies
• Date: Friday, August 22, 2025
• Time: 6:45PM ET/3:45PM PT
• Venue: Citizens Bank Park

Dimers.com's in-depth preview of Friday's Nationals vs. Phillies matchup includes our prediction, picks and the latest betting odds.

Before making any Nationals vs. Phillies picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Phillies, with a 62% win probability, will likely beat the Nationals on Friday.

AI and automation have enhanced this article to quickly deliver accurate Nationals vs. Phillies insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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