Nationals vs. Yankees prediction: Yankees favored to win Wednesday's MLB matchup [8/27/2025]

MLB action continues on Wednesday at 1:05PM ET as the Washington Nationals face off with the favored New York Yankees at Yankee Stadium.

Max Fried (13-5, 3.14 ERA) will start for the Yankees, pitting him against Cade Cavalli (1-0, 2.82 ERA) for the Nationals.

Based on the latest simulation results, Dimers' proven MLB model projects the Yankees as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Nationals-Yankees game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Yankees' chance of winning at 70%, with the Nationals at 30%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Nationals vs. Yankees predictions page.

Yankees vs. Nationals prediction: Who will win, cover the run line?

Using innovative machine learning and data, we have simulated the outcome of Wednesday's MLB game between the Nationals and Yankees 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Yankees a 70% chance of defeating the Nationals.

According to our model, the Yankees (-1.5) have a 52% chance of covering the run line, while the over/under total of 8.5 runs has a 51% chance of staying under.

Nationals vs. Yankees odds [8/27/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Nationals	Yankees
Run Line	+1.5 (+112)	-1.5 (-130)
Moneyline	+235	-275
Total	o8.5 (-104)	u8.5 (-112)

All odds are correct at the time of publication and are subject to change.

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Nationals vs. Yankees picks and best bets

Our model's strongest edge in today's Nationals vs. Yankees matchup is on the total.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets video

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Nationals vs. Yankees game-day updates and essential details

Wednesday's MLB game between the Yankees and Nationals at Yankee Stadium is scheduled to begin at 1:05PM ET.

• Who: Washington Nationals vs. New York Yankees
• Date: Wednesday, August 27, 2025
• Time: 1:05PM ET/10:05AM PT
• Venue: Yankee Stadium

Dimers.com's in-depth preview of Wednesday's Nationals vs. Yankees matchup includes our prediction, picks and the latest betting odds.

Before making any Nationals vs. Yankees picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Yankees, with a 70% win probability, will likely beat the Nationals on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Nationals vs. Yankees insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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