Nationals vs. Mets prediction: Mets favored to win Sunday's MLB matchup [9/21/2025]

The New York Mets will square off with the Washington Nationals in MLB action at Citi Field on Sunday, commencing at 1:40PM ET.

The Mets will send Sean Manaea (2-3, 5.40 ERA) to the mound, while the Nationals have opted for Jake Irvin (8-13, 5.76 ERA).

Based on updated simulation results, Dimers' advanced MLB model projects the Mets as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Nationals-Mets game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Mets with a win probability of 72%, while the Nationals have 28%."

For expanded analysis of Sunday's matchup, including best bets and picks, visit our interactive Nationals vs. Mets predictions page.

Mets vs. Nationals prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the result of Sunday's MLB matchup between the Nationals and Mets 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Mets a 72% chance of defeating the Nationals.

According to our model, the Mets (-1.5) have a 53% chance of covering the run line, while the over/under total of 8.5 runs has a 54% chance of going over.

Nationals vs. Mets odds [9/21/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Nationals	Mets
Run Line	+1.5 (+112)	-1.5 (-126)
Moneyline	+239	-275
Total	o8.5 (-110)	u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

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Nationals vs. Mets picks and best bets

Our model's strongest edge in today's Nationals vs. Mets matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Nationals vs. Mets game-day updates and essential details

Sunday's MLB matchup between the Mets and Nationals at Citi Field is scheduled to commence at 1:40PM ET.

• Who: Washington Nationals vs. New York Mets
• Date: Sunday, September 21, 2025
• Time: 1:40PM ET/10:40AM PT
• Venue: Citi Field

Dimers' comprehensive preview of Sunday's Nationals vs. Mets matchup includes our prediction, picks and the latest betting odds.

Before making any Nationals vs. Mets picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Mets, with a 72% win probability, will likely beat the Nationals on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Nationals vs. Mets insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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