Nationals vs. Marlins prediction: Why Miami is favored to win Wednesday's MLB matchup [9/10/2025]

The Miami Marlins will square off with the Washington Nationals in MLB action at loanDepot park on Wednesday, beginning at 6:40PM ET.

The Marlins will have Eury Pérez (6-5, 4.66 ERA) as their starting pitcher, while the Nationals have opted for Jake Irvin (8-11, 5.71 ERA).

Based on the latest simulation results, Dimers' advanced MLB model predicts the Marlins as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Nationals-Marlins game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Marlins' chance of winning at 56%, with the Nationals at 44%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Nationals vs. Marlins predictions page.

Marlins vs. Nationals prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the result of Wednesday's MLB game between the Nationals and Marlins 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Marlins a 56% chance of beating the Nationals.

According to our model, the Nationals (+1.5) have a 62% chance of covering the run line, while the 8.5-run over/under has an equal 50-50 chance of hitting.

Nationals vs. Marlins odds [9/10/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Nationals	Marlins
Run Line	+1.5 (-159)	-1.5 (+140)
Moneyline	+133	-150
Total	o8.5 (-115)	u8.5 (-101)

All odds are correct at the time of publication and are subject to change.

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Nationals vs. Marlins picks and best bets

Our model's strongest edge in today's Nationals vs. Marlins matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Nationals vs. Marlins game-day updates and essential details

Wednesday's MLB matchup between the Marlins and Nationals at loanDepot park is scheduled to commence at 6:40PM ET.

• Who: Washington Nationals vs. Miami Marlins
• Date: Wednesday, September 10, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: loanDepot park

Dimers' in-depth preview of Wednesday's Nationals vs. Marlins matchup includes our prediction, picks and the latest betting odds.

Before making any Nationals vs. Marlins picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Marlins, with a 56% win probability, will likely beat the Nationals on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Nationals vs. Marlins insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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