Nationals vs. Cubs prediction: Why Cubs are favored to win Saturday's MLB matchup [9/6/2025]

The Chicago Cubs and Washington Nationals will lock horns in MLB action at Wrigley Field on Saturday, starting at 2:20PM ET.

The Cubs will send Matthew Boyd (12-7, 2.94 ERA) to the mound, while the Nationals will counter with Brad Lord (4-8, 4.34 ERA).

Based on the latest simulation results, Dimers' proven MLB model projects the Cubs as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including best bets and picks, visit our interactive Nationals vs. Cubs predictions page.

Cubs vs. Nationals prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the outcome of Saturday's MLB matchup between the Nationals and Cubs 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Cubs a 69% chance of defeating the Nationals.

According to our model, the bookmakers have got it right, and the Nationals and Cubs each have a 50% chance of covering the run line, while the 8.5-run over/under has a 53% chance of going over.

Nationals vs. Cubs odds [9/6/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Nationals	Cubs
Run Line	+1.5 (+108)	-1.5 (-120)
Moneyline	+220	-260
Total	o8.5 (-118)	u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

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Nationals vs. Cubs picks and best bets

Our model's biggest edge in today's Nationals vs. Cubs matchup is on the over/under.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Nationals vs. Cubs game-day updates and essential details

Saturday's MLB game between the Cubs and Nationals at Wrigley Field is scheduled to start at 2:20PM ET.

• Who: Washington Nationals vs. Chicago Cubs
• Date: Saturday, September 6, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers.com's full preview of Saturday's Nationals vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Nationals vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cubs, with a 69% win probability, will likely beat the Nationals on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Nationals vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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