Nationals vs. Cubs prediction: Why Cubs are favored to win Friday's MLB matchup [9/5/2025]

The Chicago Cubs will square off with the Washington Nationals in MLB action at Wrigley Field on Friday, starting at 2:20PM ET.

The Cubs will have Javier Assad (1-1, 4.05 ERA) as their starting pitcher, up against Jake Irvin (8-10, 5.42 ERA) for the Nationals.

Based on the latest simulation results, Dimers' advanced MLB model predicts the Cubs as the most likely winner of today's game.

For further insights into Friday's matchup, including best bets and picks, visit our interactive Nationals vs. Cubs predictions page.

Cubs vs. Nationals prediction: Who will win, cover the run line?

Using trusted machine learning and data analysis, we have simulated the outcome of Friday's MLB matchup between the Nationals and Cubs 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Cubs a 63% chance of defeating the Nationals.

According to our model, the Nationals (+1.5) have a 54% chance of covering the run line, while the 10.5-run over/under has a 54% chance of staying under.

Nationals vs. Cubs odds [9/5/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Nationals	Cubs
Run Line	+1.5 (-105)	-1.5 (-109)
Moneyline	+184	-207
Total	o10.5 (-105)	u10.5 (-107)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Nationals vs. Cubs picks and best bets

Our model's strongest edge in today's Nationals vs. Cubs matchup is on the total.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Nationals vs. Cubs game-day updates and essential details

Friday's MLB action between the Cubs and Nationals at Wrigley Field is scheduled to start at 2:20PM ET.

• Who: Washington Nationals vs. Chicago Cubs
• Date: Friday, September 5, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers.com's comprehensive preview of Friday's Nationals vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Nationals vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Sports betting deal available for Kansas sports fans

To make the most of Friday's exciting day of sports, headlined by the Chiefs-Chargers NFL Brazil clash, check out details on the latest Bet365 bonus code "DIMERS" that secures $300 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

We predict the Cubs, with a 63% win probability, will likely beat the Nationals on Friday.

AI and automation have enhanced this article to quickly deliver accurate Nationals vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds offer the latest probabilities for the World Series, American League, National League and each division.