Nationals vs. Orioles Prediction: Baltimore Predicted to Win Saturday's MLB Matchup [5/17/2025]

The Baltimore Orioles will square off with the Washington Nationals in MLB action at Oriole Park at Camden Yards on Saturday, commencing at 4:05PM ET.

Kyle Gibson (0-2, 13.11 ERA) will start for the Orioles, while the Nationals have opted for Jake Irvin (2-1, 4.00 ERA).

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Orioles as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's Washington-Baltimore game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Orioles are more likely to win, while the Nationals have a lower chance of victory."

For a closer look at Saturday's matchup, including best bets and picks, visit our interactive Nationals vs. Orioles predictions page.

Orioles vs. Nationals Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Saturday's MLB game between the Nationals and Orioles 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Orioles a 58% chance of defeating the Nationals.

According to our model, the Nationals (+1.5) have a 59% chance of covering the run line, while the 10.5-run over/under has a 54% chance of staying under.

Nationals vs. Orioles Odds [5/17/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Nationals	Orioles
Run Line	+1.5 (-148)	-1.5 (+128)
Moneyline	+130	-148
Total	o10.5 (-115)	u10.5 (+102)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Nationals vs. Orioles Picks and Best Bets

Our model's biggest edge in today's Nationals vs. Orioles matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Nationals vs. Orioles Game-Day Updates and Essential Details

Saturday's MLB game between the Orioles and Nationals at Oriole Park at Camden Yards is scheduled to start at 4:05PM ET.

• Who: Washington Nationals vs. Baltimore Orioles
• Date: Saturday, May 17, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: Oriole Park at Camden Yards

Dimers.com's full preview of Saturday's Nationals vs. Orioles matchup includes our prediction, picks and the latest betting odds.

Before making any Washington vs. Baltimore picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Sports Betting Deals Available for Saturday

To make the most of Saturday's enormous day of sports, headlined by a massive slate of baseball, check out details on the latest Bet365 bonus code "DIMERS" that unlocks the choice of two excellent signup promotions. Don't miss out!

Conclusion

We predict the Orioles, with a 58% win probability, will likely beat the Nationals on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Nationals vs. Orioles insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay up-to-date with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most accurate predictions for the World Series, American League, National League and each division.