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Nationals vs. Orioles Prediction: Baltimore Predicted to Win Friday's MLB Matchup [5/16/2025]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Our expert prediction for Friday's Washington Nationals vs Baltimore Orioles matchup.
The Baltimore Orioles and Washington Nationals will lock horns in MLB action at Oriole Park at Camden Yards on Friday, starting at 7:05PM ET.
Cade Povich (1-3, 5.55 ERA) will be the starting pitcher for the Orioles, while the Nationals are going with MacKenzie Gore (2-4, 3.59 ERA).
Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Orioles as the most likely winner of today's game.
"Employing the latest data, our experts simulated Friday's Washington-Baltimore game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.
"After computing the latest updates and thousands of other inputs, we predict the Orioles' chance of winning is 53%, while the Nationals' is 47%."
For further insights into Friday's matchup, including best bets and picks, visit our interactive Nationals vs. Orioles predictions page.
Orioles vs. Nationals Prediction: Who Will Win, Cover the Run Line?
Using trusted machine learning and data, we have simulated the result of Friday's MLB game between the Nationals and Orioles 10,000 times as part of our MLB predictions coverage.
Our famous predictive model gives the Orioles a 53% chance of beating the Nationals.
According to our model, the Nationals (+1.5) have a 66% chance of covering the run line, while the over/under total of 9 runs has a 57% chance of staying under.
Nationals vs. Orioles Odds [5/16/2025]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Nationals | Orioles |
|---|---|---|
| Run Line | +1.5 (-198) | -1.5 (+165) |
| Moneyline | +105 | -120 |
| Total | o9 (+100) | u9 (-120) |
All odds are correct at the time of publication and are subject to change.
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Nationals vs. Orioles Picks and Best Bets
Our model's biggest edge in today's Nationals vs. Orioles matchup is on the run line.
Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.
Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.
Calling Our Shot's Best Bets Video
Calling Our Shot produces daily MLB betting content, including the predictions featured below.
Nationals vs. Orioles Game-Day Updates and Essential Details
Friday's MLB action between the Orioles and Nationals at Oriole Park at Camden Yards is scheduled to commence at 7:05PM ET.
- Who: Washington Nationals vs. Baltimore Orioles
- Date: Friday, May 16, 2025
- Time: 7:05PM ET/4:05PM PT
- Venue: Oriole Park at Camden Yards
Dimers.com's full preview of Friday's Nationals vs. Orioles matchup includes our prediction, picks and the latest betting odds.
Before making any Washington vs. Baltimore picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.
Key MLB Betting Guides and Insights
- Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion
We predict the Orioles, with a 53% win probability, will likely beat the Nationals on Friday.
AI and automation have enhanced this article to quickly deliver accurate Nationals vs. Orioles insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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More on MLB
Keep up with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most accurate projections for the World Series, American League, National League and each division.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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