Washington Commanders vs. Los Angeles Chargers early prediction: Expert picks for NFL Week 5, 2025

The Washington Commanders and Los Angeles Chargers will meet in Week 5 of the NFL season at SoFi Stadium on Sunday, October 5, 2025, starting at 4:25PM ET.

Early simulations from Dimers' trusted NFL model favor the Chargers as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Commanders vs. Chargers predictions page.

Washington vs. LA Chargers early predictions

Leveraging trusted machine learning and analysis, we have simulated the Commanders vs. Chargers game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Commanders 45%, Chargers 55%
• Predicted final score: Commanders 23-24 Chargers
• Spread: Commanders (+1.5) 50%, Chargers (-1.5) 50%
• Total points (47.5): Over 50%, Under 50%

As of September 28, 2025, these Commanders-Chargers numbers and predictions reflect the latest data and insights available.

Commanders vs. Chargers Week 5 details

The NFL Week 5 game between the Chargers and Commanders at SoFi Stadium is scheduled for October 5, 2025.

• Who: Washington Commanders vs. Los Angeles Chargers
• Date: Sunday, October 5, 2025
• Time: 4:25PM ET/1:25PM PT
• Venue: SoFi Stadium

Commanders vs. Chargers opening odds

We've researched the best betting odds across America for this Week 5 game, which are listed here:

• Spread: Commanders +1.5 (-115), Chargers -1.5 (-105)
• Moneyline: Commanders +105, Chargers -125
• Total: Over/Under 47.5 (-112/-108)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Chargers, with a 55% win probability, will likely beat the Commanders in Week 5 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Commanders vs. Chargers matchup, with human oversight maintaining high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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