Villanova vs. Penn State prediction: Why Penn State is favored to win in college football Week 3, 2025

Penn State and Villanova will lock horns in Week 3 college football action at West Shore Home Field at Beaver Stadium on Saturday, beginning at 3:30PM ET.

Based on the latest simulations, Dimers' proven college football model projects Penn State as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Villanova vs. Penn State predictions page.

Villanova vs. Penn State prediction: Who will win, cover the spread?

Using innovative machine learning and data analysis, we have simulated the result of Villanova vs. Penn State 10,000 times as part of our college football predictions coverage.

Our famous predictive model currently gives Penn State a 100% chance of beating Villanova. Our predicted final score has Penn State winning 50-3.

According to our model, the bookmakers have got it right, and Villanova and Penn State each have a 50% chance of covering the spread, while the 56.5-point over/under has a 54% chance of going over.

Villanova vs. Penn State odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Villanova	Penn State
Spread	+47.5 (-105)	-47.5 (-110)
Moneyline	+8000	-100000
Total	o56.5 (-110)	u56.5 (-108)

All odds are correct at the time of publication and are subject to change.

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Villanova vs. Penn State picks and best bets

Our model's biggest edge in today's Villanova vs. Penn State matchup is on the spread.

Our expert predictions, aligned with the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Villanova vs. Penn State game-day updates and essential details

Saturday's college football matchup between Penn State and Villanova at West Shore Home Field at Beaver Stadium is scheduled to commence at 3:30PM ET.

• Who: Villanova vs. Penn State
• Date: Saturday, September 13, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: West Shore Home Field at Beaver Stadium

Dimers' full preview of Saturday's Villanova vs. Penn State matchup includes our prediction, picks and the latest betting odds.

Before making any Villanova vs. Penn State picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Penn State, with a 100% win probability, will likely beat Villanova on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Villanova vs. Penn State insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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