Vikings vs. 49ers Predictions and Odds - Nov 28, 2021

The San Francisco 49ers and Minnesota Vikings clash in Week 12 of the NFL season at Levi's Stadium on Sunday, starting at 4:25 PM EST.

Dimers' top betting picks for Vikings vs. 49ers, plus game predictions and best odds, are featured in this article.

Who will win Vikings vs. 49ers?

Using trusted computer power and data, Dimers.com has simulated Sunday's Vikings-49ers matchup 10,000 times.

Dimers' independent predictive analytics model, DimersBOT, gives the 49ers a 59% chance of defeating the Vikings.

MORE: Vikings vs. 49ers Simulated 10,000 Times

Vikings vs. 49ers Point Spread, Moneyline and Over/Under

The 49ers are -4 favorites at home to the Vikings, with -110 at BetMGM the best odds available.

For the underdog Vikings (+4) to cover the spread, BetMGM also has the best odds on offer at -110.

BetMGM has the best moneyline odds for the 49ers at -189. That means you can risk $189 to win $100, for a total payout of $289, if they get the W.

Meanwhile, FanDuel Sportsbook has the best moneyline odds for the Vikings at +176, where you can bet $100 to profit $176, earning a total payout of $276, if they win.

The Over/Under is set at 48.5 with PointsBet, which has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, check out all the legal sportbooks that are available in your state for the best NFL odds and lines.

According to DimersBOT, the Vikings (+4) are a 65% chance of covering the spread, while the 48.5-point Over/Under is a 51% chance of going Over.

MORE: Best Bets Today for All Major Sports

Best Bets for Vikings vs. 49ers

• Spread: Vikings +4 at -110 with BetMGM (65% probability) 🔥
• Moneyline: Vikings Win at +176 with FanDuel Sportsbook (4.5% edge) 🔥
• Over/Under: Over 48.5 at -110 with PointsBet (51% probability)

If you see a 🔥, that means it's one of our best free picks of the day across all sports.

While the 49ers are more likely to win the game, according to DimersBOT, taking the Vikings moneyline is the best option due to the 4.5% edge identified when comparing our data-led probabilities to the betting odds.

Taking advantage of the edges seen on Dimers.com is pivotal to being profitable in the long run.

Vikings vs. 49ers Score Prediction

Dimers.com's predicted final score for Minnesota vs. San Francisco at Levi's Stadium this Sunday has the 49ers winning 25-23.

Use our interactive widget below to explore the latest Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup to reveal more.

Dimers has full coverage of this week's Vikings-49ers matchup, including pre-game predictions, computer picks, and live win probabilities.

Remember, DimersBOT updates often, so refresh this page for the latest betting insights before Vikings vs. 49ers on Sunday November 28, 2021.

Vikings vs. 49ers 2021 Game Info

When do the 49ers play the Vikings?

• Date: Sunday November 28, 2021
• Time: 4:25 PM EST / 1:25 PM PST
• Venue: Levi's Stadium

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We use the power of predictive analytics to find value in the markets so we can write the most comprehensive NFL betting previews out there. We're able to do this by comparing our own probabilities against the sportsbooks' odds (aka Vegas odds) as soon as they go live.

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