Vanderbilt vs. South Carolina prediction: South Carolina favored to win in college football Week 3, 2025

South Carolina and Vanderbilt will meet in Week 3 college football action at Williams-Brice Stadium on Saturday, commencing at 7:45PM ET.

Based on the latest simulation results, Dimers' advanced college football model predicts South Carolina as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Vanderbilt vs. South Carolina predictions page.

Vanderbilt vs. South Carolina prediction: Who will win, cover the spread?

Using powerful machine learning and data, we have simulated the result of Vanderbilt vs. South Carolina 10,000 times as part of our college football predictions coverage.

Our independent predictive model gives South Carolina a 58% chance of defeating Vanderbilt. Our predicted final score has South Carolina winning 26-23.

According to our model, Vanderbilt (+3.5) has a 56% chance of covering the spread, while the 48.5-point over/under has a 52% chance of staying under.

Vanderbilt vs. South Carolina odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Vanderbilt	South Carolina
Spread	+3.5 (-115)	-3.5 (-105)
Moneyline	+126	-140
Total	o48.5 (-110)	u48.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Vanderbilt vs. South Carolina picks and best bets

Our model's strongest edge in today's Vanderbilt vs. South Carolina matchup is on the over/under.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Vanderbilt vs. South Carolina game-day updates and essential details

Saturday's college football matchup between South Carolina and Vanderbilt at Williams-Brice Stadium is scheduled to start at 7:45PM ET.

• Who: Vanderbilt vs. South Carolina
• Date: Saturday, September 13, 2025
• Time: 7:45PM ET/4:45PM PT
• Venue: Williams-Brice Stadium

Dimers' in-depth preview of Saturday's Vanderbilt vs. South Carolina matchup includes our prediction, picks and the latest betting odds.

Before making any Vanderbilt vs. South Carolina picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict South Carolina, with a 58% win probability, will likely beat Vanderbilt on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Vanderbilt vs. South Carolina insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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