US Open Tennis Predictions: Wednesday best bets featuring Sinner vs. Musetti in quarterfinals

The 2025 US Open continues in New York City on Wednesday, September 3 for Day 11 of the tournament and the end of the quarterfinals at Flushing Meadows. The fourth and final Grand Slam of the year runs through to Championship Sunday on September 7 and as the tournament advances, we have the latest US Open best bets and tennis predictions.

The Dimers model has had a productive first half of the tournament, including a 2-0 day on our best High Value bets from Day 3 of the US Open, nailing Jannik Sinner as our top bet on Day 5 and another 2-0 result on Day 6 with bets on Carlos Alcaraz and Novak Djokovic and 2-0 again on Day 9 with Sinner and de Minaur before another 2-0 day yesterday.

The favorites of the tournament are all still in play, but darkhorses like Amanda Anisimova and Naomi Osaka could shake things up in the quarterfinals.

Add in Dimers’ biggest betting offering ever—expanded markets, new bet types, and broader sportsbook coverage—and there’s never been a better time to bet on the US Open.

Best Value Bets for US Open Quarterfinals - Wednesday, September 3

Dimers highlights “High Value” bets when favorable odds line up with strong probability.

While only one bet gets a "High Value" signal from the Dimers model, there are several more at a lower value still worth a look.

Jannik Sinner -7.5 vs. Lorenzo Musetti

• Court: Arthur Ashe Stadium
• Time: 7:00 PM ET
• Win Probability: 61.0%
• Edge: 4.4%
• Best Odds: -130 (Caesars Sportsbook)

This is both our highest probability and best value play today. Sinner has dropped just one set throughout this tournament and the dimers model strongly backs him to keep his elite form in the quraterfinals.

See our full match predictions for Sinner vs. Musetti on Wednesday, including Moneyline and Game Totals.

Iga Swiatek vs. Amanda Anisimova Under 21.5 Games

• Court: Arthur Ashe Stadium
• Time: 1:00 PM ET
• Win Probability: 59.3%
• Edge: 2.8%
• Best Odds: –130 (BetMGM Sportsbook)

Our second-highest probability of the day, our model predicts a tight match between Swiatek and Anisimova, who is one of our pre-tournament value picks to win. To see more bets from this match, view our full match predictions for Swiatek-Anisimova on Wednesday afternoon.

To find more value bets, including some moneyline upsets and more, check out Dimers' Best Tennis Bets every day of the US Open.

Betting the US Open Smartly

The opening round is all about balance—taking advantage of sharp value edges while recognizing the volatility of early rounds. Heavy favorites like Iga Switek and Jannik Sinner look like strong bets to advance, while Dimers’ Day 11 “High Value” picks provide bettors with calculated opportunities. Keep an eye on Felix Auger-Aliassiame vs. Alex de Minaur, our closest projected match of the second day of quarterfinals.

With Flushing Meadows buzzing, the 2025 US Open is primed for drama, and Dimers is giving bettors every tool they need to play it smart.

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