UCLA vs. Northwestern prediction: Northwestern favored to win in college football Week 5, 2025

Northwestern and UCLA will lock horns in Week 5 college football action at Northwestern Medicine Field at Martin Stadium on Saturday, starting at 3:30PM ET.

Based on the latest simulation results, Dimers' proven college football model projects Northwestern as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive UCLA vs. Northwestern predictions page.

UCLA vs. Northwestern prediction: Who will win, cover the spread?

Using innovative machine learning and data, we have simulated the outcome of UCLA vs. Northwestern 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives Northwestern a 60% chance of defeating UCLA. Our predicted final score has Northwestern winning 25-21.

According to our model, UCLA (+6.5) has a 56% chance of covering the spread, while the over/under total of 45.5 points has a 57% chance of staying under.

UCLA vs. Northwestern odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	UCLA	Northwestern
Spread	+6.5 (-115)	-6.5 (-105)
Moneyline	+185	-220
Total	o45.5 (-110)	u45.5 (-110)

All odds are correct at the time of publication and are subject to change.

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UCLA vs. Northwestern picks and best bets

Our model's strongest edge in today's UCLA vs. Northwestern matchup is on the spread.

Our expert predictions, matched against the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

UCLA vs. Northwestern game-day updates and essential details

Saturday's college football matchup between Northwestern and UCLA at Northwestern Medicine Field at Martin Stadium is scheduled to commence at 3:30PM ET.

• Who: UCLA vs. Northwestern
• Date: Saturday, September 27, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: Northwestern Medicine Field at Martin Stadium

Dimers' full preview of Saturday's UCLA vs. Northwestern matchup includes our prediction, picks and the latest betting odds.

Before making any UCLA vs. Northwestern picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict Northwestern, with a 60% win probability, will likely beat UCLA on Saturday.

AI and automation have enhanced this article to quickly deliver accurate UCLA vs. Northwestern insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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