Tulane vs. South Alabama prediction: Tulane favored to win in college football Week 2, 2025

South Alabama will face the favored Tulane in Week 2 college football action at Hancock Whitney Stadium on Saturday, starting at 7:00PM ET.

Based on updated simulation results, Dimers' proven college football model predicts Tulane as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Tulane vs. South Alabama predictions page.

Tulane vs. South Alabama prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the outcome of Tulane vs. South Alabama 10,000 times as part of our college football predictions coverage.

Our leading predictive model gives Tulane an 82% chance of beating South Alabama. Our predicted final score has Tulane winning 31-18.

According to our model, the bookmakers have got it right, and Tulane and South Alabama each have a 50% chance of covering the spread, while the 51.5-point over/under also has an equal 50-50 chance of hitting.

Tulane vs. South Alabama odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Tulane	South Alabama
Spread	-13.5 (-110)	+13.5 (-105)
Moneyline	-550	+410
Total	o51.5 (-105)	u51.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Tulane vs. South Alabama picks and best bets

Our model's strongest edge in today's Tulane vs. South Alabama matchup is on the spread.

Our expert predictions, matched against the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Tulane vs. South Alabama game-day updates and essential details

Saturday's college football game between South Alabama and Tulane at Hancock Whitney Stadium is scheduled to begin at 7:00PM ET.

• Who: Tulane vs. South Alabama
• Date: Saturday, September 6, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: Hancock Whitney Stadium

Dimers.com's full preview of Saturday's Tulane vs. South Alabama matchup includes our prediction, picks and the latest betting odds.

Before making any Tulane vs. South Alabama picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Tulane, with an 82% win probability, will likely beat South Alabama on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Tulane vs. South Alabama insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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