Tulane vs. Ole Miss prediction: Why Mississippi is favored to win in college football Week 4, 2025

Mississippi and Tulane will clash in Week 4 college football action at Vaught-Hemingway Stadium on Saturday, beginning at 3:30PM ET.

Based on updated simulations, Dimers' advanced college football model predicts Mississippi as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Tulane vs. Ole Miss predictions page.

Tulane vs. Ole Miss prediction: Who will win, cover the spread?

Using innovative machine learning and statistical analysis, we have simulated the result of Tulane vs. Ole Miss 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives Mississippi a 75% chance of defeating Tulane. Our predicted final score has Mississippi winning 34-23.

According to our model, Tulane (+12.5) has a 51% chance of covering the spread, while the over/under total of 61.5 points has a 62% chance of going over.

Tulane vs. Ole Miss odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Tulane	Ole Miss
Spread	+12.5 (-112)	-12.5 (-105)
Moneyline	+340	-440
Total	o61.5 (-110)	u61.5 (-110)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Tulane vs. Ole Miss picks and best bets

Our model's biggest edge in today's Tulane vs. Ole Miss matchup is on the spread.

Our expert predictions, aligned with the latest odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Tulane vs. Ole Miss game-day updates and essential details

Saturday's college football matchup between Ole Miss and Tulane at Vaught-Hemingway Stadium is scheduled to commence at 3:30PM ET.

• Who: Tulane vs. Mississippi
• Date: Saturday, September 20, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: Vaught-Hemingway Stadium

Dimers' comprehensive preview of Saturday's Tulane vs. Ole Miss matchup includes our prediction, picks and the latest betting odds.

Before making any Tulane vs. Ole Miss picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Sports betting deal available for NCAAF Saturday

To make the most of Saturday's mammoth day of sports, headlined by clashes like this one for college football Saturday, check out details on the latest Bet365 bonus code "DIMERS" that grants you $200 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

We predict Mississippi, with a 75% win probability, will likely beat Tulane on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Tulane vs. Mississippi insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on college football

Stay informed with the latest college football betting news and CFB parlay picks throughout the season. Plus, our College Football National Championship odds provide the latest probabilities for the national title game and major conferences.