Troy vs. Buffalo prediction: Buffalo favored to win in college football Week 4, 2025

Buffalo will take on Troy in Week 4 college football action at UB Stadium on Saturday, beginning at 3:30PM ET.

Based on the latest simulations, Dimers' advanced college football model projects Buffalo as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Troy vs. Buffalo predictions page.

Troy vs. Buffalo prediction: Who will win, cover the spread?

Using powerful machine learning and data, we have simulated the result of Troy vs. Buffalo 10,000 times as part of our college football predictions coverage.

Our independent predictive model gives Buffalo a 61% chance of defeating Troy. Our predicted final score has Buffalo winning 24-21.

According to our model, Troy (+5.5) has a 54% chance of covering the spread, while the over/under total of 43.5 points has a 56% chance of staying under.

Troy vs. Buffalo odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Troy	Buffalo
Spread	+5.5 (-110)	-5.5 (-110)
Moneyline	+185	-210
Total	o43.5 (-118)	u43.5 (-102)

All odds are correct at the time of publication and are subject to change.

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Troy vs. Buffalo picks and best bets

Our model's biggest edge in today's Troy vs. Buffalo matchup is on the spread.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Troy vs. Buffalo game-day updates and essential details

Saturday's college football matchup between Buffalo and Troy at UB Stadium is scheduled to start at 3:30PM ET.

• Who: Troy vs. Buffalo
• Date: Saturday, September 20, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: UB Stadium

Dimers' in-depth preview of Saturday's Troy vs. Buffalo matchup includes our prediction, picks and the latest betting odds.

Before making any Troy vs. Buffalo picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Buffalo, with a 61% win probability, will likely beat Troy on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Troy vs. Buffalo insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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