Blue Jays vs. Rays prediction: Why Toronto is favored to win Wednesday's MLB matchup [9/17/2025]

The Tampa Bay Rays will take on the Toronto Blue Jays in MLB action at George M. Steinbrenner Field on Wednesday, commencing at 7:05PM ET.

Ian Seymour (3-2, 2.95 ERA) will be on the bump for the Rays, while the Blue Jays have opted for Kevin Gausman (10-10, 3.44 ERA).

Based on updated simulation results, Dimers' advanced MLB model predicts the Blue Jays as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Blue Jays-Rays game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Blue Jays' chance of winning at 52%, with the Rays at 48%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Blue Jays vs. Rays predictions page.

Rays vs. Blue Jays prediction: Who will win, cover the run line?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Wednesday's MLB matchup between the Blue Jays and Rays 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Blue Jays a 52% chance of defeating the Rays.

According to our model, the Rays (+1.5) have a 62% chance of covering the run line, while the 7.5-run over/under has a 52% chance of going over.

Blue Jays vs. Rays odds [9/17/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Blue Jays	Rays
Run Line	-1.5 (+136)	+1.5 (-160)
Moneyline	-130	+110
Total	o7.5 (+112)	u7.5 (-120)

All odds are correct at the time of publication and are subject to change.

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Blue Jays vs. Rays picks and best bets

Our model's strongest edge in today's Blue Jays vs. Rays matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Blue Jays vs. Rays game-day updates and essential details

Wednesday's MLB game between the Rays and Blue Jays at George M. Steinbrenner Field is scheduled to commence at 7:05PM ET.

• Who: Toronto Blue Jays vs. Tampa Bay Rays
• Date: Wednesday, September 17, 2025
• Time: 7:05PM ET/4:05PM PT
• Venue: George M. Steinbrenner Field

Dimers' comprehensive preview of Wednesday's Blue Jays vs. Rays matchup includes our prediction, picks and the latest betting odds.

Before making any Blue Jays vs. Rays picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Blue Jays, with a 52% win probability, will likely beat the Rays on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Blue Jays vs. Rays insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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