Blue Jays vs. Yankees prediction: Yankees favored to win Friday's MLB matchup [9/5/2025]

The New York Yankees will face the Toronto Blue Jays, in what is expected to be a tight MLB game, at Yankee Stadium on Friday, commencing at 7:05PM ET.

The Yankees will start Cam Schlittler (2-2, 2.61 ERA), pitting him against Kevin Gausman (8-10, 3.75 ERA) for the Blue Jays.

Based on updated simulation results, Dimers' proven MLB model predicts the Yankees as the most likely winner of today's game.

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Blue Jays vs. Yankees predictions page.

Yankees vs. Blue Jays prediction: Who will win, cover the run line?

Using powerful machine learning and data analysis, we have simulated the result of Friday's MLB matchup between the Blue Jays and Yankees 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Yankees a 53% chance of beating the Blue Jays.

According to our model, the Blue Jays (+1.5) have a 63% chance of covering the run line, while the 9-run over/under has a 51% chance of going over.

Blue Jays vs. Yankees odds [9/5/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Blue Jays	Yankees
Run Line	+1.5 (-190)	-1.5 (+160)
Moneyline	+108	-120
Total	o9 (-110)	u9 (-106)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Blue Jays vs. Yankees picks and best bets

Our model's biggest edge in today's Blue Jays vs. Yankees matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Blue Jays vs. Yankees game-day updates and essential details

Friday's MLB game between the Yankees and Blue Jays at Yankee Stadium is scheduled to commence at 7:05PM ET.

• Who: Toronto Blue Jays vs. New York Yankees
• Date: Friday, September 5, 2025
• Time: 7:05PM ET/4:05PM PT
• Venue: Yankee Stadium

Dimers.com's comprehensive preview of Friday's Blue Jays vs. Yankees matchup includes our prediction, picks and the latest betting odds.

Before making any Blue Jays vs. Yankees picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Sports betting deal available for Kansas sports fans

To make the most of Friday's exciting day of sports, headlined by the Chiefs-Chargers NFL Brazil clash, check out details on the latest Bet365 bonus code "DIMERS" that unlocks $300 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

We predict the Yankees, with a 53% win probability, will likely beat the Blue Jays on Friday.

AI and automation have enhanced this article to quickly deliver accurate Blue Jays vs. Yankees insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay informed with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most up-to-date probabilities for the World Series, American League, National League and each division.