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Blue Jays vs. Royals prediction: Toronto favored to win Sunday's MLB matchup [9/21/2025]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get Toronto Blue Jays vs Kansas City Royals predictions for MLB Sunday.
The Kansas City Royals will square off with the Toronto Blue Jays in MLB action at Kauffman Stadium on Sunday, commencing at 2:10PM ET.
The Royals will send Michael Wacha (9-12, 3.79 ERA) to the mound, while the Blue Jays have opted for Trey Yesavage (0-0, 1.80 ERA).
Based on updated simulation results, Dimers' advanced MLB model predicts the Blue Jays as the most likely winner of today's game.
"Using the most recent data, our experts ran 10,000 simulations of Sunday's Blue Jays-Royals game," said Dimers' Chief Content Officer, Nick Slade.
"After accounting for recent updates and other variables, our prediction shows the Blue Jays with a win probability of 55%, while the Royals have 45%."
For further insights into Sunday's matchup, including best bets and picks, visit our interactive Blue Jays vs. Royals predictions page.
Royals vs. Blue Jays prediction: Who will win, cover the run line?
Using innovative machine learning and data, we have simulated the result of Sunday's MLB matchup between the Blue Jays and Royals 10,000 times as part of our MLB predictions coverage.
Our famous predictive model gives the Blue Jays a 55% chance of defeating the Royals.
According to our model, the Royals (+1.5) have a 58% chance of covering the run line, while the 8.5-run over/under has a 55% chance of going over.
Blue Jays vs. Royals odds [9/21/2025]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Blue Jays | Royals |
|---|---|---|
| Run Line | -1.5 (+135) | +1.5 (-152) |
| Moneyline | -124 | +106 |
| Total | o8.5 (-110) | u8.5 (-101) |
All odds are correct at the time of publication and are subject to change.
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Blue Jays vs. Royals picks and best bets
Our model's biggest edge in today's Blue Jays vs. Royals matchup is on the run line.
Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.
Unlimited access to our full set of picks, including this one, is available via Dimers Pro.
Calling Our Shot's best bets
Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.
Blue Jays vs. Royals game-day updates and essential details
Sunday's MLB action between the Royals and Blue Jays at Kauffman Stadium is scheduled to begin at 2:10PM ET.
- Who: Toronto Blue Jays vs. Kansas City Royals
- Date: Sunday, September 21, 2025
- Time: 2:10PM ET/11:10AM PT
- Venue: Kauffman Stadium
Dimers' in-depth preview of Sunday's Blue Jays vs. Royals matchup includes our prediction, picks and the latest betting odds.
Before making any Blue Jays vs. Royals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.
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Conclusion
We predict the Blue Jays, with a 55% win probability, will likely beat the Royals on Sunday.
AI and automation have enhanced this article to quickly deliver accurate Blue Jays vs. Royals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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