Blue Jays vs. Guardians Prediction: Cleveland Predicted to Win Wednesday's MLB Matchup [6/25/2025]

The Cleveland Guardians will face the Toronto Blue Jays, in what is expected to be a tight MLB game, at Progressive Field on Wednesday, starting at 6:40PM ET.

The Guardians will have Gavin Williams (5-3, 3.58 ERA) as their starting pitcher, pitting him against Max Scherzer (0-0, 6.00 ERA) for the Blue Jays.

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Guardians as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Blue Jays-Guardians game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Guardians' chance of winning at 52%, with the Blue Jays at 48%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Blue Jays vs. Guardians predictions page.

Guardians vs. Blue Jays Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data analysis, we have simulated the outcome of Wednesday's MLB game between the Blue Jays and Guardians 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Guardians a 52% chance of beating the Blue Jays.

According to our model, the Blue Jays (+1.5) have a 66% chance of covering the run line, while the over/under total of 8 runs has an equal 50-50 chance of hitting.

Blue Jays vs. Guardians Odds [6/25/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Blue Jays	Guardians
Run Line	+1.5 (-205)	-1.5 (+168)
Moneyline	+102	-120
Total	o8 (-106)	u8 (-108)

All odds are correct at the time of publication and are subject to change.

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Blue Jays vs. Guardians Picks and Best Bets

Our model's biggest edge in today's Blue Jays vs. Guardians matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Blue Jays vs. Guardians Game-Day Updates and Essential Details

Wednesday's MLB action between the Guardians and Blue Jays at Progressive Field is scheduled to begin at 6:40PM ET.

• Who: Toronto Blue Jays vs. Cleveland Guardians
• Date: Wednesday, June 25, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Progressive Field

Dimers.com's comprehensive preview of Wednesday's Blue Jays vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any Blue Jays vs. Guardians picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Guardians, with a 52% win probability, will likely beat the Blue Jays on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Blue Jays vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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