Blue Jays vs. Reds prediction: Why Toronto is favored to win Wednesday's MLB matchup [9/3/2025]

The Cincinnati Reds will take on the Toronto Blue Jays in MLB action at Great American Ball Park on Wednesday, commencing at 6:40PM ET.

The Reds will send Zack Littell (9-8, 3.63 ERA) to the mound, pitting him against Shane Bieber (1-1, 2.38 ERA) for the Blue Jays.

Based on the latest simulation results, Dimers' proven MLB model projects the Blue Jays as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Blue Jays-Reds game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Blue Jays' chance of winning at 59%, with the Reds at 41%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Blue Jays vs. Reds predictions page.

Reds vs. Blue Jays prediction: Who will win, cover the run line?

Using trusted machine learning and statistical analysis, we have simulated the result of Wednesday's MLB game between the Blue Jays and Reds 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Blue Jays a 59% chance of beating the Reds.

According to our model, the Reds (+1.5) have a 54% chance of covering the run line, while the over/under total of 9 runs has an equal 50-50 chance of hitting.

Blue Jays vs. Reds odds [9/3/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Blue Jays	Reds
Run Line	-1.5 (+108)	+1.5 (-120)
Moneyline	-152	+135
Total	o9 (+100)	u9 (-117)

All odds are correct at the time of publication and are subject to change.

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Blue Jays vs. Reds picks and best bets

Our model's biggest edge in today's Blue Jays vs. Reds matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Blue Jays vs. Reds game-day updates and essential details

Wednesday's MLB matchup between the Reds and Blue Jays at Great American Ball Park is scheduled to begin at 6:40PM ET.

• Who: Toronto Blue Jays vs. Cincinnati Reds
• Date: Wednesday, September 3, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Great American Ball Park

Dimers.com's full preview of Wednesday's Blue Jays vs. Reds matchup includes our prediction, picks and the latest betting odds.

Before making any Blue Jays vs. Reds picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Blue Jays, with a 59% win probability, will likely beat the Reds on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Blue Jays vs. Reds insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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