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This Kyler Murray Prop Is the Best Bet for Thursday Night Football
Find out why this Kyler Murray player prop is the best bet for Thursday Night Football when the Cardinals tackle the Seahawks, as NFL Week 4 gets underway at State Farm Stadium.

The Arizona Cardinals are set to host the Seattle Seahawks in a pivotal Week 4 Thursday Night Football matchup. While the Cardinals are tipped to lose by 2 points in a predicted 22 - 20 game at State Farm Stadium, quarterback Kyler Murray's expected rushing performance still stands out as the best bet of the night.
Kyler Murray has consistently demonstrated his ability to make plays with his legs, having recorded more than 28.5 rushing yards in 5 of his last 6 appearances. This includes rushing for 38 yards, 32 yards, and 37 yards in his first three games of the 2025 season.
So, when looking at the NFL best bets for this Thursday Night Football game, one player prop bet stands out as a top-tier play: Kyler Murray over 28.5 rushing yards (-108).
His career average of 40.2 rushing yards against the Seahawks further reinforces his historical success in this matchup.
Followers of this article should be sitting pretty after Jahmyr Gibbs cashed our Monday Night Football best bet earlier in the week.
Kyler Murray Over 28.5 rushing yards is the best bet of the night in TNF.
The statistical projections for this game also heavily favor the over. Murray's predicted rushing yards total, according to Dimers' player projections hub, is 31.7, which is a comfortable margin above the 28.5-yard line at the sports betting sites. This projection suggests that he is likely to exceed the total, making the over an attractive bet.
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The Seahawks' defense, while generally strong, has shown a recent vulnerability to rushing quarterbacks.The Cardinals will likely need to rely on Murray's elusiveness to combat Seattle's pass rush.
With Murray's a less-than-healthy offensive line, designed runs and scrambles from the pocket are expected.
Given Murray's recent trend of exceeding this rushing total, his strong history against the Seahawks, and a projected game script that should lead to him using his legs, the Kyler Murray Over 28.5 Rushing Yards prop is the top bet to make for Thursday Night Football.
The best NFL odds for this prop are -108, which provides excellent value for a bet with a high probability of success.
READ: Full Cardinals vs. Seahawks Thursday Night Football Preview