Rangers vs. Astros prediction: Cy Young candidate Jacob deGrom takes on Houston tonight [9/17/2025]

The Houston Astros will square off with the Texas Rangers, in what is expected to be a close MLB game, at Daikin Park on Wednesday, starting at 8:10PM ET.

Cristian Javier (1-3, 4.78 ERA) will start for the Astros, up against Cy Young hopeful Jacob deGrom (12-7, 2.82 ERA) for the Rangers.

Based on the latest simulation results, Dimers' advanced MLB model predicts the Rangers as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Rangers-Astros game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Rangers' chance of winning at 52%, with the Astros at 48%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Rangers vs. Astros predictions page.

Astros vs. Rangers prediction: Who will win, cover the run line?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Wednesday's MLB matchup between the Rangers and Astros 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Rangers a 52% chance of defeating the Astros.

According to our model, the Astros (+1.5) have a 60% chance of covering the run line, while the over/under total of 7.5 runs has a 56% chance of going over.

Rangers vs. Astros odds [9/17/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Rangers	Astros
Run Line	-1.5 (+140)	+1.5 (-154)
Moneyline	-125	+114
Total	o7.5 (-105)	u7.5 (-112)

All odds are correct at the time of publication and are subject to change.

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Rangers vs. Astros picks and best bets

Our model's strongest edge in today's Rangers vs. Astros matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Rangers vs. Astros game-day updates and essential details

Wednesday's MLB game between the Astros and Rangers at Daikin Park is scheduled to begin at 8:10PM ET.

• Who: Texas Rangers vs. Houston Astros
• Date: Wednesday, September 17, 2025
• Time: 8:10PM ET/5:10PM PT
• Venue: Daikin Park

Dimers' full preview of Wednesday's Rangers vs. Astros matchup includes our prediction, picks and the latest betting odds.

Before making any Rangers vs. Astros picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Rangers, with a 52% win probability, will likely beat the Astros on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Rangers vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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