Tennessee vs. Mississippi State prediction: Why Tennessee is favored to win in college football Week 5, 2025

Mississippi State will face the favored Tennessee in Week 5 college football action at Davis Wade Stadium at Scott Field on Saturday, beginning at 4:15PM ET.

Based on updated simulations, Dimers' proven college football model predicts Tennessee as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Tennessee vs. Mississippi State predictions page.

Tennessee vs. Mississippi State prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the outcome of Tennessee vs. Mississippi State 10,000 times as part of our college football predictions coverage.

Our leading predictive model gives Tennessee a 67% chance of defeating Mississippi State. Our predicted final score has Tennessee winning 33-26.

According to our model, the bookies have got it right, and Tennessee and Mississippi State each have a 50% chance of covering the spread, while the 63.5-point over/under has a 57% chance of going over.

Tennessee vs. Mississippi State odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Tennessee	Mississippi State
Spread	-7.5 (-104)	+7.5 (-112)
Moneyline	-280	+235
Total	o63.5 (-108)	u63.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Tennessee vs. Mississippi State picks and best bets

Our model's strongest edge in today's Tennessee vs. Mississippi State matchup is on the spread.

Our expert predictions, matched against the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Tennessee vs. Mississippi State game-day updates and essential details

Saturday's college football game between Mississippi State and Tennessee at Davis Wade Stadium at Scott Field is scheduled to commence at 4:15PM ET.

• Who: Tennessee vs. Mississippi State
• Date: Saturday, September 27, 2025
• Time: 4:15PM ET/1:15PM PT
• Venue: Davis Wade Stadium at Scott Field

Dimers' full preview of Saturday's Tennessee vs. Mississippi State matchup includes our prediction, picks and the latest betting odds.

Before making any Tennessee vs. Mississippi State picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict Tennessee, with a 67% win probability, will likely beat Mississippi State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Tennessee vs. Mississippi State insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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