Tennessee Titans vs. Houston Texans early prediction: Expert picks for NFL Week 4, 2025

The Tennessee Titans and Houston Texans will meet in Week 4 of the NFL season at NRG Stadium on Sunday, September 28, 2025, starting at 1:00PM ET.

Initial simulations from Dimers' trusted NFL model favor the Texans as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Titans vs. Texans predictions page.

Tennessee vs. Houston early predictions

Leveraging trusted machine learning and analysis, we have simulated the Titans vs. Texans game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Titans 30%, Texans 70%
• Predicted final score: Titans 19-24 Texans
• Spread: Titans (+6.5) 55%, Texans (-6.5) 45%
• Total points (44.5): Over 50%, Under 50%

As of September 21, 2025, these Titans-Texans numbers and predictions reflect the latest data and insights available.

Titans vs. Texans Week 4 details

The NFL Week 4 matchup between the Texans and Titans at NRG Stadium is scheduled for September 28, 2025.

• Who: Tennessee Titans vs. Houston Texans
• Date: Sunday, September 28, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: NRG Stadium

Titans vs. Texans opening odds

We've researched the best betting odds across America for this Week 4 game, which are listed here:

• Spread: Titans +6.5 (-115), Texans -6.5 (-105)
• Moneyline: Titans +210, Texans -235
• Total: Over/Under 44.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Texans, with a 70% win probability, will likely beat the Titans in Week 4 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Titans vs. Texans matchup, with human oversight maintaining high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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