Tennessee Titans vs. Denver Broncos early prediction: Expert picks for NFL Week 1, 2025

The Tennessee Titans and Denver Broncos will meet in Week 1 of the NFL season at Empower Field at Mile High on Sunday, September 7, 2025, starting at 4:05PM ET.

Initial simulations from Dimers' trusted NFL model favor the Broncos as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Titans vs. Broncos predictions page.

Tennessee vs. Denver early predictions

Leveraging trusted machine learning and analysis, we have simulated the Titans vs. Broncos game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Titans 22%, Broncos 78%
• Predicted final score: Titans 17-24 Broncos
• Spread: Titans (+8) 54%, Broncos (-8) 46%
• Total points (41.5): Over 50%, Under 50%

As of August 31, 2025, these Titans-Broncos numbers and predictions reflect the latest data and insights available.

Titans vs. Broncos Week 1 details

The NFL Week 1 matchup between the Broncos and Titans at Empower Field at Mile High is scheduled for September 7, 2025.

• Who: Tennessee Titans vs. Denver Broncos
• Date: Sunday, September 7, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: Empower Field at Mile High

Titans vs. Broncos opening odds

We've researched the best betting odds across America for this Week 1 game, which are listed here:

• Spread: Titans +8 (-110), Broncos -8 (-110)
• Moneyline: Titans +340, Broncos -395
• Total: Over/Under 41.5 (-110/-108)

Odds may continue to move—track live changes via our NFL odds page.

NFL Week 1 betting promos and codes

Make the most of Dimers' Titans vs. Broncos predictions by exploring the two exciting offers below.

DraftKings Sportsbook

Sign up for DraftKings Sportsbook! Bet $5, get $300 in Bonus Bets instantly plus over $200 off NFL Sunday Ticket.

Bet365 Sportsbook

Join Bet365 Sportsbook! Bet $5, get $200 in Bonus Bets win or lose.

Conclusion

We predict the Broncos, with a 78% win probability, will likely beat the Titans in Week 1 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Titans vs. Broncos game, with human oversight maintaining high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee.

More on NFL

Stay up-to-date with the latest NFL betting news and data-driven parlay picks all season long. Plus, our Super Bowl odds for top predictions and the best available odds on the Super Bowl, AFC, NFC and each division.