Tennessee Titans vs. Arizona Cardinals early prediction: Expert picks for NFL Week 5, 2025

The Tennessee Titans and Arizona Cardinals will meet in Week 5 of the NFL season at State Farm Stadium on Sunday, October 5, 2025, starting at 4:05PM ET.

Initial simulations from Dimers' trusted NFL model favor the Cardinals as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Titans vs. Cardinals predictions page.

Tennessee vs. Arizona early predictions

Leveraging trusted machine learning and analysis, we have simulated the Titans vs. Cardinals game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Titans 31%, Cardinals 69%
• Predicted final score: Titans 20-25 Cardinals
• Spread: Titans (+5.5) 50%, Cardinals (-5.5) 50%
• Total points (46.5): Over 50%, Under 50%

As of September 28, 2025, these Titans-Cardinals numbers and predictions reflect the latest data and insights available.

Titans vs. Cardinals Week 5 details

The NFL Week 5 action between the Cardinals and Titans at State Farm Stadium is scheduled for October 5, 2025.

• Who: Tennessee Titans vs. Arizona Cardinals
• Date: Sunday, October 5, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: State Farm Stadium

Titans vs. Cardinals opening odds

We've researched the best betting odds across America for this Week 5 game, which are listed here:

• Spread: Titans +5.5 (-110), Cardinals -5.5 (-110)
• Moneyline: Titans +195, Cardinals -238
• Total: Over/Under 46.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Cardinals, with a 69% win probability, will likely beat the Titans in Week 5 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Titans vs. Cardinals matchup, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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