Rays vs. Guardians prediction: Why Tampa Bay is favored to win Wednesday's MLB matchup [8/27/2025]

MLB action continues on Wednesday at 1:10PM ET as the Tampa Bay Rays square off with the Cleveland Guardians at Progressive Field.

Slade Cecconi (5-6, 4.41 ERA) will be the starting pitcher for the Guardians, while the Rays are going with Drew Rasmussen (10-5, 2.62 ERA).

Based on updated simulations, Dimers' proven MLB model predicts the Rays as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Rays-Guardians game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Rays' chance of winning at 57%, with the Guardians at 43%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Rays vs. Guardians predictions page.

Guardians vs. Rays prediction: Who will win, cover the run line?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Wednesday's MLB game between the Rays and Guardians 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Rays a 57% chance of beating the Guardians.

According to our model, the Guardians (+1.5) have a 56% chance of covering the run line, while the over/under total of 7 runs has a 57% chance of going over.

Rays vs. Guardians odds [8/27/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Rays	Guardians
Run Line	-1.5 (+120)	+1.5 (-138)
Moneyline	-148	+128
Total	o7 (-112)	u7 (-105)

All odds are correct at the time of publication and are subject to change.

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Rays vs. Guardians picks and best bets

Our model's biggest edge in today's Rays vs. Guardians matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

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Rays vs. Guardians game-day updates and essential details

Wednesday's MLB matchup between the Guardians and Rays at Progressive Field is scheduled to start at 1:10PM ET.

• Who: Tampa Bay Rays vs. Cleveland Guardians
• Date: Wednesday, August 27, 2025
• Time: 1:10PM ET/10:10AM PT
• Venue: Progressive Field

Dimers.com's in-depth preview of Wednesday's Rays vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any Rays vs. Guardians picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Rays, with a 57% win probability, will likely beat the Guardians on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Rays vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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