Rays vs. Guardians prediction: Tight battle projected in updated analysis for Monday's MLB matchup [8/25/2025]

The Cleveland Guardians will square off with the Tampa Bay Rays, in what is expected to be a tight MLB game, at Progressive Field on Monday, starting at 6:40PM ET.

The Guardians will send Tanner Bibee (9-9, 4.62 ERA) to the mound, while the Rays are going with Ian Seymour (1-0, 3.86 ERA).

Based on the latest simulation results, Dimers' proven MLB model predicts an equal chance for both the Guardians and Rays to win today's game.

For further insights into Monday's matchup, including best bets and picks, visit our interactive Rays vs. Guardians predictions page.

Guardians vs. Rays prediction: Who will win, cover the run line?

Using powerful machine learning and data analysis, we have simulated the result of Monday's MLB matchup between the Rays and Guardians 10,000 times as part of our MLB predictions coverage.

Our independent predictive model can't split the two teams, giving both the Rays and Guardians a 50% chance of winning the game.

According to our model, the Rays (+1.5) have a 66% chance of covering the run line, while the 7.5-run over/under has a 52% chance of going over.

Rays vs. Guardians odds [8/25/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Rays	Guardians
Run Line	+1.5 (-201)	-1.5 (+172)
Moneyline	+102	-118
Total	o7.5 (-105)	u7.5 (-114)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Rays vs. Guardians picks and best bets

Our model's strongest edge in today's Rays vs. Guardians matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Rays vs. Guardians game-day updates and essential details

Monday's MLB game between the Guardians and Rays at Progressive Field is scheduled to commence at 6:40PM ET.

• Who: Tampa Bay Rays vs. Cleveland Guardians
• Date: Monday, August 25, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Progressive Field

Dimers.com's full preview of Monday's Rays vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any Rays vs. Guardians picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict a close game between the Rays and Guardians on Monday, with each team having a 50% chance of winning.

AI and automation have enhanced this article to quickly deliver accurate Rays vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds offer the latest probabilities for the World Series, American League, National League and each division.