Rays vs. Cubs prediction: Close contest projected after new data released for Saturday's MLB matchup [9/13/2025]

The Chicago Cubs will face the Tampa Bay Rays, in what is expected to be a close MLB game, at Wrigley Field on Saturday, beginning at 2:20PM ET.

Colin Rea (10-6, 4.20 ERA) will be the starting pitcher for the Cubs, pitting him against Drew Rasmussen (10-5, 2.64 ERA) for the Rays.

Based on updated simulations, Dimers' proven MLB model predicts an equal chance for both the Cubs and Rays to win today's game.

For a closer look at Saturday's matchup, including best bets and picks, visit our interactive Rays vs. Cubs predictions page.

Cubs vs. Rays prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the outcome of Saturday's MLB matchup between the Rays and Cubs 10,000 times as part of our MLB predictions coverage.

Our independent predictive model can't split the two teams, giving both the Rays and Cubs a 50% chance of winning the game.

According to our model, the Cubs (+1.5) have a 62% chance of covering the run line, while the over/under total of 8 runs has a 55% chance of going over.

Rays vs. Cubs odds [9/13/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Rays	Cubs
Run Line	-1.5 (+155)	+1.5 (-176)
Moneyline	-108	-108
Total	o8 (-112)	u8 (-102)

All odds are correct at the time of publication and are subject to change.

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Rays vs. Cubs picks and best bets

Our model's strongest edge in today's Rays vs. Cubs matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Rays vs. Cubs game-day updates and essential details

Saturday's MLB game between the Cubs and Rays at Wrigley Field is scheduled to commence at 2:20PM ET.

• Who: Tampa Bay Rays vs. Chicago Cubs
• Date: Saturday, September 13, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers' comprehensive preview of Saturday's Rays vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Rays vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict a close game between the Rays and Cubs on Saturday, with each team having a 50% chance of winning.

AI and automation have enhanced this article to quickly deliver accurate Rays vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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