Rays vs. Cubs prediction: Why Cubs are favored to win Friday's MLB matchup [9/12/2025]

MLB action continues on Friday at 2:20PM ET as the Tampa Bay Rays lock horns with the Chicago Cubs at Wrigley Field.

Matthew Boyd (12-8, 2.92 ERA) will get the ball for the Cubs, pitting him against Shane Baz (9-11, 4.94 ERA) for the Rays.

Based on updated simulation results, Dimers' advanced MLB model predicts the Cubs as the most likely winner of today's game.

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Rays vs. Cubs predictions page.

Cubs vs. Rays prediction: Who will win, cover the run line?

Using powerful machine learning and data analysis, we have simulated the outcome of Friday's MLB matchup between the Rays and Cubs 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Cubs a 61% chance of beating the Rays.

According to our model, the Rays (+1.5) have a 58% chance of covering the run line, while the over/under total of 7 runs has a 55% chance of going over.

Rays vs. Cubs odds [9/12/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Rays	Cubs
Run Line	+1.5 (-154)	-1.5 (+137)
Moneyline	+136	-162
Total	o7 (-107)	u7 (-105)

All odds are correct at the time of publication and are subject to change.

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Rays vs. Cubs picks and best bets

Our model's biggest edge in today's Rays vs. Cubs matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

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Rays vs. Cubs game-day updates and essential details

Friday's MLB matchup between the Cubs and Rays at Wrigley Field is scheduled to start at 2:20PM ET.

• Who: Tampa Bay Rays vs. Chicago Cubs
• Date: Friday, September 12, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers' in-depth preview of Friday's Rays vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Rays vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cubs, with a 61% win probability, will likely beat the Rays on Friday.

AI and automation have enhanced this article to quickly deliver accurate Rays vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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