Rays vs. Orioles prediction: Baltimore favored to win Wednesday's MLB matchup [9/24/2025]

MLB action continues on Wednesday at 6:35PM ET as the Tampa Bay Rays lock horns with the Baltimore Orioles at Oriole Park at Camden Yards.

The Orioles will send Tyler Wells (2-0, 2.04 ERA) to the mound, up against Shane Baz (10-12, 4.99 ERA) for the Rays.

Based on updated simulations, Dimers' proven MLB model predicts the Orioles as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Rays-Orioles game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Orioles' chance of winning at 52%, with the Rays at 48%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Rays vs. Orioles predictions page.

Orioles vs. Rays prediction: Who will win, cover the run line?

Using powerful machine learning and data analysis, we have simulated the outcome of Wednesday's MLB matchup between the Rays and Orioles 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Orioles a 52% chance of beating the Rays.

According to our model, the Rays (+1.5) have a 66% chance of covering the run line, while the 8-run over/under has a 58% chance of going over.

Rays vs. Orioles odds [9/24/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Rays	Orioles
Run Line	+1.5 (-196)	-1.5 (+162)
Moneyline	+106	-120
Total	o8 (-102)	u8 (-107)

All odds are correct at the time of publication and are subject to change.

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Rays vs. Orioles picks and best bets

Our model's strongest edge in today's Rays vs. Orioles matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

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Rays vs. Orioles game-day updates and essential details

Wednesday's MLB action between the Orioles and Rays at Oriole Park at Camden Yards is scheduled to start at 6:35PM ET.

• Who: Tampa Bay Rays vs. Baltimore Orioles
• Date: Wednesday, September 24, 2025
• Time: 6:35PM ET/3:35PM PT
• Venue: Oriole Park at Camden Yards

Dimers' in-depth preview of Wednesday's Rays vs. Orioles matchup includes our prediction, picks and the latest betting odds.

Before making any Rays vs. Orioles picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Orioles, with a 52% win probability, will likely beat the Rays on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Rays vs. Orioles insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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