Rays vs. Diamondbacks Prediction: Arizona Predicted to Win Tuesday's MLB Matchup [4/22/2025]

The Arizona Diamondbacks and Tampa Bay Rays are scheduled to meet in MLB action at Chase Field on Tuesday, starting at 9:40PM ET.

The Diamondbacks will send Brandon Pfaadt (3-1, 3.04 ERA) to the mound, up against Zack Littell (0-4, 5.48 ERA) for the Rays.

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Diamondbacks as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's Tampa Bay-Arizona game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Diamondbacks with a win probability of 61%, compared to 39% for the Rays."

For a closer look at Tuesday's matchup, including best bets and picks, visit our interactive Rays vs. Diamondbacks predictions page.

Diamondbacks vs. Rays Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the result of Tuesday's MLB matchup between the Rays and Diamondbacks 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Diamondbacks a 61% chance of defeating the Rays.

According to our model, the Rays (+1.5) have a 60% chance of covering the run line, while the over/under total of 9 runs has a 54% chance of staying under.

Rays vs. Diamondbacks Odds [4/22/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Rays	Diamondbacks
Run Line	+1.5 (-130)	-1.5 (+112)
Moneyline	+160	-178
Total	o9 (-114)	u9 (-105)

All odds are correct at the time of publication and are subject to change.

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Rays vs. Diamondbacks Picks and Best Bets

Our model's biggest edge in today's Rays vs. Diamondbacks matchup is on the over/under.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Rays vs. Diamondbacks Game-Day Updates and Essential Details

Tuesday's MLB action between the Diamondbacks and Rays at Chase Field is scheduled to begin at 9:40PM ET.

• Who: Tampa Bay Rays vs. Arizona Diamondbacks
• Date: Tuesday, April 22, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: Chase Field

Dimers.com's full preview of Tuesday's Rays vs. Diamondbacks matchup includes our prediction, picks and the latest betting odds.

Before making any Tampa Bay vs. Arizona picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Diamondbacks, with a 61% win probability, will likely beat the Rays on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Rays vs. Diamondbacks insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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