Tampa Bay Buccaneers vs. Seattle Seahawks early prediction: Expert picks for NFL Week 5, 2025

The Tampa Bay Buccaneers and Seattle Seahawks will meet in Week 5 of the NFL season at Lumen Field on Sunday, October 5, 2025, starting at 4:05PM ET.

Initial simulations from Dimers' trusted NFL model favor the Buccaneers as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Buccaneers vs. Seahawks predictions page.

Tampa Bay vs. Seattle early predictions

Leveraging trusted machine learning and analysis, we have simulated the Bucs vs. Seahawks game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Buccaneers 59%, Seahawks 41%
• Predicted final score: Buccaneers 24-21 Seahawks
• Spread: Buccaneers (-1.5) 53%, Seahawks (+1.5) 47%
• Total points (47.5): Over 46%, Under 54%

As of September 28, 2025, these Buccaneers-Seahawks calculations and predictions reflect the latest data and insights available.

Bucs vs. Seahawks Week 5 details

The NFL Week 5 matchup between the Seahawks and Buccaneers at Lumen Field is scheduled for October 5, 2025.

• Who: Tampa Bay Buccaneers vs. Seattle Seahawks
• Date: Sunday, October 5, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: Lumen Field

Bucs vs. Seahawks opening odds

We've researched the best betting odds across America for this Week 5 game, which are listed here:

• Spread: Buccaneers -1.5 (-108), Seahawks +1.5 (-112)
• Moneyline: Buccaneers -125, Seahawks +105
• Total: Over/Under 47.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Buccaneers, with a 59% win probability, will likely beat the Seahawks in Week 5 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Buccaneers vs. Seahawks matchup, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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