Syracuse vs. Tennessee prediction: Why Tennessee is favored to win in college football Week 1, 2025

Tennessee and Syracuse will clash in college football action at Mercedes-Benz Stadium on Saturday, beginning at 12:00PM ET.

Based on the latest simulation results, Dimers' advanced college football model predicts Tennessee as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Syracuse vs. Tennessee predictions page.

Syracuse vs. Tennessee prediction: Who will win, cover the spread?

Using innovative machine learning and data, we have simulated the result of Syracuse vs. Tennessee 10,000 times as part of our college football predictions coverage.

Our leading predictive model gives Tennessee a 79% chance of beating Syracuse. Our predicted final score has Tennessee winning 31-19.

According to our model, Syracuse (+13.5) has a 53% chance of covering the spread, while the over/under total of 51.5 points has an equal 50-50 chance of hitting.

Syracuse vs. Tennessee odds

We have sourced the best College Football odds in America for this game, which are listed here:

Bet Type	Syracuse	Tennessee
Spread	+13.5 (-110)	-13.5 (-110)
Moneyline	+375	-500
Total	o51.5 (-114)	u51.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Syracuse vs. Tennessee picks and best bets

Our model's strongest edge in today's Syracuse vs. Tennessee matchup is on the total.

Our expert predictions, matched against the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Syracuse vs. Tennessee game-day updates and essential details

Saturday's college football matchup between Tennessee and Syracuse at Mercedes-Benz Stadium is scheduled to start at 12:00PM ET.

• Who: Syracuse vs. Tennessee
• Date: Saturday, August 30, 2025
• Time: 12:00PM ET/9:00AM PT
• Venue: Mercedes-Benz Stadium

Dimers.com's full preview of Saturday's Syracuse vs. Tennessee matchup includes our prediction, picks and the latest betting odds.

Before making any Syracuse vs. Tennessee picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Tennessee, with a 79% win probability, will likely beat Syracuse on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Syracuse vs. Tennessee insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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