Syracuse vs. Clemson prediction: Why Clemson is favored to win in college football Week 4, 2025

Clemson and Syracuse will lock horns in Week 4 college football action at Memorial Stadium on Saturday, starting at 12:00PM ET.

Based on the latest simulation results, Dimers' proven college football model predicts Clemson as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Syracuse vs. Clemson predictions page.

Syracuse vs. Clemson prediction: Who will win, cover the spread?

Using innovative machine learning and data analysis, we have simulated the result of Syracuse vs. Clemson 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives Clemson an 86% chance of defeating Syracuse. Our predicted final score has Clemson winning 36-18.

According to our model, Clemson (-14.5) has a 54% chance of covering the spread, while the 54.5-point over/under has a 54% chance of staying under.

Syracuse vs. Clemson odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Syracuse	Clemson
Spread	+14.5 (-110)	-14.5 (-120)
Moneyline	+600	-660
Total	o54.5 (-105)	u54.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Syracuse vs. Clemson picks and best bets

Our model's strongest edge in today's Syracuse vs. Clemson matchup is on the spread.

Our expert predictions, matched against the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Syracuse vs. Clemson game-day updates and essential details

Saturday's college football matchup between Clemson and Syracuse at Memorial Stadium is scheduled to commence at 12:00PM ET.

• Who: Syracuse vs. Clemson
• Date: Saturday, September 20, 2025
• Time: 12:00PM ET/9:00AM PT
• Venue: Memorial Stadium

Dimers' in-depth preview of Saturday's Syracuse vs. Clemson matchup includes our prediction, picks and the latest betting odds.

Before making any Syracuse vs. Clemson picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Clemson, with an 86% win probability, will likely beat Syracuse on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Syracuse vs. Clemson insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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