Cardinals vs. Rays prediction: Why Tampa Bay is favored to win Friday's MLB matchup [8/22/2025]

MLB action continues on Friday at 7:35PM ET as the St. Louis Cardinals square off with the Tampa Bay Rays at George M. Steinbrenner Field.

The Rays will start Adrian Houser (6-4, 2.67 ERA), pitting him against Miles Mikolas (6-9, 4.99 ERA) for the Cardinals.

Based on the latest simulation results, Dimers' advanced MLB model projects the Rays as the most likely winner of today's game.

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Cardinals vs. Rays predictions page.

Rays vs. Cardinals prediction: Who will win, cover the run line?

Using innovative machine learning and data analysis, we have simulated the result of Friday's MLB game between the Cardinals and Rays 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Rays a 55% chance of defeating the Cardinals.

According to our model, the Cardinals (+1.5) have a 61% chance of covering the run line, while the over/under total of 8.5 runs has a 51% chance of going over.

Cardinals vs. Rays odds [8/22/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Rays
Run Line	+1.5 (-182)	-1.5 (+151)
Moneyline	+120	-137
Total	o8.5 (-124)	u8.5 (+102)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Rays picks and best bets

Our model's biggest edge in today's Cardinals vs. Rays matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

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Cardinals vs. Rays game-day updates and essential details

Friday's MLB action between the Rays and Cardinals at George M. Steinbrenner Field is scheduled to commence at 7:35PM ET.

• Who: St. Louis Cardinals vs. Tampa Bay Rays
• Date: Friday, August 22, 2025
• Time: 7:35PM ET/4:35PM PT
• Venue: George M. Steinbrenner Field

Dimers.com's comprehensive preview of Friday's Cardinals vs. Rays matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Rays picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Rays, with a 55% win probability, will likely beat the Cardinals on Friday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Rays insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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