Cardinals vs. Mariners prediction: Seattle favored to win Wednesday's MLB matchup [9/10/2025]

The Seattle Mariners will face the St. Louis Cardinals in MLB action at T-Mobile Park on Wednesday, starting at 9:40PM ET.

The Mariners will send Logan Gilbert (4-6, 3.61 ERA) to the mound, while the Cardinals have opted for Michael McGreevy (6-3, 4.68 ERA).

Based on updated simulation results, Dimers' advanced MLB model predicts the Mariners as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Cardinals-Mariners game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Mariners' chance of winning at 67%, with the Cardinals at 33%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Cardinals vs. Mariners predictions page.

Mariners vs. Cardinals prediction: Who will win, cover the run line?

Using innovative machine learning and data analysis, we have simulated the outcome of Wednesday's MLB game between the Cardinals and Mariners 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Mariners a 67% chance of defeating the Cardinals.

According to our model, the Cardinals (+1.5) have a 51% chance of covering the run line, while the over/under total of 7.5 runs has a 53% chance of going over.

Cardinals vs. Mariners odds [9/10/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Mariners
Run Line	+1.5 (-115)	-1.5 (-102)
Moneyline	+185	-220
Total	o7.5 (-103)	u7.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Mariners picks and best bets

Our model's biggest edge in today's Cardinals vs. Mariners matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Cardinals vs. Mariners game-day updates and essential details

Wednesday's MLB matchup between the Mariners and Cardinals at T-Mobile Park is scheduled to begin at 9:40PM ET.

• Who: St. Louis Cardinals vs. Seattle Mariners
• Date: Wednesday, September 10, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: T-Mobile Park

Dimers' in-depth preview of Wednesday's Cardinals vs. Mariners matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Mariners picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Mariners, with a 67% win probability, will likely beat the Cardinals on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Mariners insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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