Cardinals vs. Mariners prediction: Seattle favored to win Monday's MLB matchup [9/8/2025]

The Seattle Mariners will face the St. Louis Cardinals in MLB action at T-Mobile Park on Monday, commencing at 9:40PM ET.

The Mariners will start Bryan Woo (12-7, 3.02 ERA), while the Cardinals are going with Miles Mikolas (7-10, 4.88 ERA).

Based on updated simulations, Dimers' advanced MLB model predicts the Mariners as the most likely winner of today's game.

For a closer look at Monday's matchup, including best bets and picks, visit our interactive Cardinals vs. Mariners predictions page.

Mariners vs. Cardinals prediction: Who will win, cover the run line?

Using trusted machine learning and data analysis, we have simulated the result of Monday's MLB matchup between the Cardinals and Mariners 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Mariners a 68% chance of defeating the Cardinals.

According to our model, the bookmakers have got it right, and the Cardinals and Mariners each have a 50% chance of covering the run line, while the over/under total of 7.5 runs has a 56% chance of going over.

Cardinals vs. Mariners odds [9/8/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Mariners
Run Line	+1.5 (-106)	-1.5 (-110)
Moneyline	+205	-246
Total	o7.5 (-120)	u7.5 (+100)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Mariners picks and best bets

Our model's biggest edge in today's Cardinals vs. Mariners matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

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Cardinals vs. Mariners game-day updates and essential details

Monday's MLB game between the Mariners and Cardinals at T-Mobile Park is scheduled to commence at 9:40PM ET.

• Who: St. Louis Cardinals vs. Seattle Mariners
• Date: Monday, September 8, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: T-Mobile Park

Dimers' full preview of Monday's Cardinals vs. Mariners matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Mariners picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Mariners, with a 68% win probability, will likely beat the Cardinals on Monday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Mariners insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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