Cardinals vs. Giants prediction: St. Louis favored to win Wednesday's MLB matchup [9/24/2025]

MLB action continues on Wednesday at 9:45PM ET as the St. Louis Cardinals lock horns with the San Francisco Giants at Oracle Park.

JT Brubaker (0-0, 3.65 ERA) will be on the bump for the Giants, pitting him against Sonny Gray (14-8, 4.33 ERA) for the Cardinals.

Based on the latest simulations, Dimers' advanced MLB model projects the Cardinals as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Cardinals-Giants game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Cardinals' chance of winning at 52%, with the Giants at 48%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Cardinals vs. Giants predictions page.

Giants vs. Cardinals prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the result of Wednesday's MLB game between the Cardinals and Giants 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Cardinals a 52% chance of beating the Giants.

According to our model, the Giants (+1.5) have a 61% chance of covering the run line, while the 7.5-run over/under has a 57% chance of going over.

Cardinals vs. Giants odds [9/24/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Giants
Run Line	-1.5 (+155)	+1.5 (-178)
Moneyline	-115	+100
Total	o7.5 (-115)	u7.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Giants picks and best bets

Our model's biggest edge in today's Cardinals vs. Giants matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets video

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Cardinals vs. Giants game-day updates and essential details

Wednesday's MLB action between the Giants and Cardinals at Oracle Park is scheduled to start at 9:45PM ET.

• Who: St. Louis Cardinals vs. San Francisco Giants
• Date: Wednesday, September 24, 2025
• Time: 9:45PM ET/6:45PM PT
• Venue: Oracle Park

Dimers' full preview of Wednesday's Cardinals vs. Giants matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Giants picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cardinals, with a 52% win probability, will likely beat the Giants on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Giants insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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