Cardinals vs. Giants prediction: San Francisco favored to win Monday's MLB matchup [9/22/2025]

The San Francisco Giants and St. Louis Cardinals will meet in MLB action at Oracle Park on Monday, starting at 9:45PM ET.

The Giants will have Justin Verlander (3-10, 3.75 ERA) as their starting pitcher, pitting him against Michael McGreevy (7-3, 4.08 ERA) for the Cardinals.

Based on updated simulation results, Dimers' advanced MLB model projects the Giants as the most likely winner of today's game.

For further insights into Monday's matchup, including best bets and picks, visit our interactive Cardinals vs. Giants predictions page.

Giants vs. Cardinals prediction: Who will win, cover the run line?

Using trusted machine learning and data analysis, we have simulated the outcome of Monday's MLB game between the Cardinals and Giants 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Giants a 57% chance of beating the Cardinals.

According to our model, the Cardinals (+1.5) have a 62% chance of covering the run line, while the 7.5-run over/under has a 58% chance of going over.

Cardinals vs. Giants odds [9/22/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Giants
Run Line	+1.5 (-175)	-1.5 (+147)
Moneyline	+126	-140
Total	o7.5 (-115)	u7.5 (-102)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Giants picks and best bets

Our model's strongest edge in today's Cardinals vs. Giants matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Cardinals vs. Giants game-day updates and essential details

Monday's MLB action between the Giants and Cardinals at Oracle Park is scheduled to start at 9:45PM ET.

• Who: St. Louis Cardinals vs. San Francisco Giants
• Date: Monday, September 22, 2025
• Time: 9:45PM ET/6:45PM PT
• Venue: Oracle Park

Dimers' full preview of Monday's Cardinals vs. Giants matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Giants picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Giants, with a 57% win probability, will likely beat the Cardinals on Monday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Giants insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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