Cardinals vs. Padres Prediction: San Diego Predicted to Win Sunday's MLB Matchup [8/3/2025]

The San Diego Padres will take on the St. Louis Cardinals in MLB action at PETCO Park on Sunday, commencing at 4:10PM ET.

Dylan Cease (3-10, 4.79 ERA) will start on the mound for the Padres, while the Cardinals will counter with Andre Pallante (6-7, 4.62 ERA).

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Padres as the most likely winner of today's game. "Using the most recent data, our experts ran 10,000 simulations of Sunday's Cardinals-Padres game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Padres with a win probability of 66%, while the Cardinals have 34%."

For a closer look at Sunday's matchup, including best bets and picks, visit our interactive Cardinals vs. Padres predictions page.

Padres vs. Cardinals Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the outcome of Sunday's MLB matchup between the Cardinals and Padres 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Padres a 66% chance of defeating the Cardinals.

According to our model, the Cardinals (+1.5) have a 54% chance of covering the run line, while the 8-run over/under has a 52% chance of staying under.

Cardinals vs. Padres Odds [8/3/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Padres
Run Line	+1.5 (-128)	-1.5 (+115)
Moneyline	+166	-198
Total	o8 (+100)	u8 (-119)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Padres Picks and Best Bets

Our model's biggest edge in today's Cardinals vs. Padres matchup is on the total.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Cardinals vs. Padres Game-Day Updates and Essential Details

Sunday's MLB action between the Padres and Cardinals at PETCO Park is scheduled to begin at 4:10PM ET.

• Who: St. Louis Cardinals vs. San Diego Padres
• Date: Sunday, August 3, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: PETCO Park

Dimers.com's in-depth preview of Sunday's Cardinals vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Padres, with a 66% win probability, will likely beat the Cardinals on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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